Medicine

Evolving ASO therapies from advancement to application

.Contending rate of interests.R.S., M.S., H.G. and also A.A.R. are coordinators of the 1M1M initiative. H.G. and also A.A.R. are actually panel of supervisors members as well as R.S., M.S. and A.A.R. are participants of the scientific consultatory board of N1C. A.A.R. reveals work by LUMC, which possesses licenses on exon-skipping technology, a number of which has actually been accredited to BioMarin and also subsequently sublicensed to Sarepta. As co-inventor of some of these patents, A.A.R. was actually qualified to an allotment of royalties. A.A.R. further reveals functioning as impromptu consultant for PTC Therapeutics, Sarepta Therapeutics, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and Astra Zeneca. Over the last 5 years, A.A.R. also carried out ad hoc seeking advice from for Alpha Anomeric. A.A.R. also reports registration of the clinical advisory boards of Eisai, Hybridize Therapeutics, Silence Rehabs, Sarepta Rehabs, Sapreme and also Mitorx. Before 5 years, A.A.R. was actually additionally a clinical advisory board participant for ProQR. Pay for A.A.R. u00e2 s consulting and suggesting activities is actually spent to LUMC. Over the last 5 years, LUMC likewise received audio speaker honoraria coming from PTC Therapies, Alnylam Netherlands, Italfarmaco as well as Pfizer as well as financing for agreement research study coming from Sapreme, Eisai, Galapagos, Synaffix as well as Alpha Anomeric. Job backing is obtained from Sarepta Rehabs and also Entrada through unregulated grants. H.G. has absolutely nothing to disclose relative to the subject matters dealt with within this composition. Previously 5 years, he has actually also acquired consultancy honoraria coming from UCB. M.S. received consultancy honoraria from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly as well as Solaxa over the last 5 years, all unrelated to the present composition. R.S. has absolutely nothing to make known in regard to the subjects covered in this particular composition. She has obtained sound speaker and/or working as a consultant gratuity or even funding payments coming from Abbvie, Bial, STADA as well as Everpharma before 5 years.