.Attribute Medicine, Released online: 13 September 2024 doi:10.1038/ s41591-024-03261-7In the non-randomized phase 3b/4 DESTINY-Breast12 research study, trastuzumab deruxtecan (T-DXd) procedure of individuals along with HER2+ sophisticated breast cancer as well as energetic or secure human brain metastases revealed steady intracranial task and also systemic efficiency of T-DXd.